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Cancer Pharmacology

An Illustrated Manual of Anticancer Drugs
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Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon malignancies. Beautifully illustrated throughout, each chapter contains visually engaging figures detailing the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic, and molecular properties of the various agents, and their mechanisms of action. As the first illustrated book of its kind, this highly visual text uses a uniform approach to each cancer drug class and agent presented in the book, and covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Flow diagrams, clinical tables, and bulleted text further explain important information pertaining to each cancer drug class including their indications, mechanisms of action, potential adverse reactions, dosing and dose adjustments, and safety monitoring. Organized in an easy-to-digest format and replete with detailed images, clinical pearls, and end of chapter Q&As, this evidence-based reference presents all major classes, agents, targets, and approaches to cancer pharmacotherapy.Whether you are a trainee, a clinical scientist, or a clinician in practice, the book is an ideal reference. It presents challenging information in an instructional way; it illustrates key concepts for ease of retention; and, it poses tough questions so readers can problem solve potential scenarios and test their pharmacologic acumen. Written by leading experts in oncopharmacology, this first-of-its kind manual is a "must have" for anyone involved in the basic, translational, or clinical aspects of oncology and hematology including clinicians, pharmacists, nurses, and trainees. Key Features: Includes visual depictions of chemical structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Describes how chemotherapy, targeted therapy, immunotherapy, hormonal therapy, work and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other modalities Over 135 highly stylized images and numerous comprehensive tables Covers challenges related to drug development, drug approval and regulatory issues in relation to anticancer treatments All chapters conclude with clinical pearls and detailed clinical Q&As with descriptive rationales Purchase includes access to the ebook for use on most mobile devices or computers
1. Anticancer Drug Development: An Introduction: Edward A. Sausville 2. Alkylating Agents: Ali Bukhari and Ashkan Emadi 3. Antimetabolites: Hydroxyurea, Pyrimidine and Purine Analogs, and L-Asparaginase: Crystal Lu, Judith E. Karp and Ashkan Emadi 4. Antimetabolites: Antifolates: Justin Lawson and Edward Sausville 5. Antimitotics: Edward A. Sausville 6. DNA Repair, Apoptotic Pathways, CDK Inhibitors: Mira A. Kohorst and Scott H. Kaufmann 7. Epigenetic Modulators: Lukasz P. Gondek 8. Differentiating Agents and Microenvironment: Gabriel Ghiaur 9. Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer: Amy Fulton and Katherine H.R. Tkaczuk 10. Male Hormonal Therapies: Arif Hussain and Vincent Njar 11. Targeted Therapies (Small Molecules): Michael G. McCusker, Jr., Katherine A. Scilla, and Christian Rolfo 12. Monoclonal Antibodies Including Immunoconjugates and Cytokine-Directed Agents: Alison Duffy and Ciera Patzke 13. Immunotherapeutics Including Vaccines, Bispecifics, CAR-T, and Checkpoint Inhibitors: Mark Yarchoan and Elizabeth Jaffee 14. Multiple Myeloma as a Paradigm for Multi-Targeted Intervention: Mehmet Kocoglu 15. Transplant-Related Agents: Jean Yared and Saurabh Dahiya 16. Basic Drug Development with Structural Considerations: Sonia Esparza and Joshua Zeidner 17. Integral Components in Development of Clinical Trials: PK/PD, Statistics, and Principles of Rational Combinatorial Therapies: S. Percy Ivy and Richard F. Little 18. Drug Approval and Regulatory Issues: Olanrewaju O. Okusanya, Ruby Leong, Matthew D. Thompson, and Donna Przepiorka
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