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Methodological Issues and Strategies in Clinical Research

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Now in its fifth edition, this classic text helps readers learn how to design, conduct, analyze, and report high-quality clinical studies. Alan E. Kazdin brings together a wide array of authoritative articles with his own expert insights to illustrate fundamental issues research in an accessible manner, including generating ideas, selecting participants, randomization, selecting assessment measures, analyzing data, and evaluating the implications of and publishing the results. New to this edition are articles emphasizing the importance of diversity in research, not only cultural diversity among study participants but also in methodology (including quantitative, qualitative, and mixed methods); the role of big data; using technology such as artificial intelligence and apps; and strategies to improve transparency and accessibility, including open science practices, replication, and preregistration. From generating hypotheses for study and selecting appropriate assessments to interpreting data and presenting findings, readers will come to better understand the whole research process as well as the importance of ethics and scientific integrity.
Alan E. Kazdin, PhD, is a research scientist and sterling professor of psychology and child psychiatry at Yale University where he also served as chairman of the psychology department, director of the Child Study Center, director of child psychiatric services, and chair of the publications committee. He has published 50 books on methodology, parenting and child rearing, psychosocial interventions, interpersonal violence, and novel treatment delivery models. His awards include the Research Scientist and MERIT Awards from the National Institute of Mental Health and the Gold Medal Award for Life Achievement in the Science of Psychology from the American Psychological Foundation.
Preface Part I. Introduction: Overview and Background Chapter 1. Methodology: What It Is and Why It Is So Important Alan E. Kazdin Part II. Beginning the Research Process Research Ideas Chapter 2. Beginning the Process: Key Concepts and Questions to Guide Research Alan E. Kazdin Chapter 3. Getting Out of Our Conceptual Ruts: Strategies for Expanding Conceptual Frameworks Allan W. Wicker Foci of Research Chapter 4. In Defense of External Invalidity Douglas G. Mook Chapter 5. When Small Effects Are Impressive Deborah A. Prentice and Dale T. Miller Part III. Participants in Research Samples and Selection of Participants Chapter 6. A WEIRD View of Human Nature Skews Psychologists' Studies Dan Jones Chapter 7. Toward a Psychology of Homo Sapiens: Making Psychological Science More Representative of the Human Population Mostafa Salari Rad, Alison Jane Martingano, and Jeremy Ginges Diversity of Participants Chapter 8. On Becoming Multicultural in a Monocultural Research World: A Conceptual Approach to Studying Ethnocultural Diversity Gordon C. Nagayama Hall, Tiffany Yip, and Michael A. Zarate Chapter 9. Designing Studies for Sex and Gender Analyses: How Research Can Derive Clinically Useful Knowledge for Women's Health Ruth Klap and Keith Humphreys Part IV. Design Options With and Without Randomization Research Designs Options Chapter 10. Experimental and Observational Designs: An Overview Alan E. Kazdin Chapter 11. Observational Studies and Their Utility for Practice Julia F. M. Gilmartin-Thomas, Danny Liew, and Ingrid Hopper Randomization and Randomized Controlled Trials Chapter 12. Random Sampling, Randomization, and Equivalence of Contrasted Groups in Psychotherapy Outcome Research Louis M. Hsu Chapter 13. Randomized Controlled Trials: Characteristics, Options, and Challenges Alan E. Kazdin Part V. Assessment Core Concepts and Considerations in Developing and Selecting Measures Chapter 14. Constructing Validity: New Developments in Creating Objective Measuring Instruments Lee Anna Clark and David Watson Chapter 15. Selecting Measures for Research Investigations Alan E. Kazdin Novel Measurement Options Chapter 16. Computer-Enhanced Practice: The Benefits of Computer-Assisted Assessment in Applied Clinical Practice Stephanie Ruth Young, Danika L. S. Maddocks, and Jacqueline M. Caemmerer Chapter 17. Ecological Momentary Assessment (EMA) in Studies of Substance Use Saul Shiffman Chapter 18. AI in Mental Health Simon D'Alfonso Part VI. Data Analysis, Evaluation, and Presentation Background and Underpinnings of Data Analyses Chapter 19. A Power Primer Jacob Cohen Chapter 20. Abandon Statistical Significance Blakeley B. McShane, David Gal, Andrew Gelman, Christian Robert, and Jennifer L. Tackett Chapter 21. Ethical Concerns in Statistical Analyses: Implications for Clinical Research and Practice Owen J. Gaasedelen Data Exploration and Multiple Methods of Data Analyses Chapter 22. Exploratory Data Analysis as a Foundation of Inductive Research Andrew T. Jebb, Scott Parrigon, and Sang Eun Woo Chapter 23. When Should We Use One-Tailed Hypothesis Testing? Graeme D. Ruxton and Markus Neuhaeuser Chapter 24. The Proof of the Pudding: An Illustration of the Relative Strengths of Null Hypothesis, Meta-Analysis, and Bayesian Analysis George S. Howard, Scott E. Maxwell, and Kevin J. Fleming Data Presentation Chapter 25. Designing Better Graphs by Including Distributional Information and Integrating Words, Numbers, and Images David M. Lane and Aniko Sandor Part VII. Special Topics: Evaluation in Clinical Practice and Research Evaluating Clinical Effects of Treatment Chapter 26. Routine Outcome Monitoring (ROM) and Feedback: Research Review and Recommendations Michael Barkham, Kim De Jong, Jaime Delgadillo, and Wolfgang Lutz Chapter 27. Revisiting and Reenvisioning the Outcome Problem in Psychotherapy: An Argument to Include Individualized and Qualitative Measurement Clara E. Hill, Harold Chui, and Ellen Baumann Extending Treatments Chapter 28. Beyond Efficacy and Effectiveness: A Multifaceted Approach to Treatment Evaluation Timothy D. Nelson and Ric G. Steele Chapter 29. Testing Psychosocial Interventions in the Contexts They Are Meant to be Delivered Rinad S. Beidas, Lisa Saldana, and Rachel C. Shelton Part VIII. Multiple Methodologies and Levels of Data Analysis Beyond Quantitative Methods Chapter 30. What Can Qualitative Psychology Contribute to Psychological Knowledge? Carla Willig Chapter 31. Mixed Methods Research in Psychology Timothy C. Guetterman and Analay Perez Chapter 32. Single-Case Experimental Research Designs Alan E. Kazdin Big Data, Secondary Data Sets, and Collaborative Science Chapter 33. Big Data in Psychology: A Framework for Research Advancement Idris Adjerid and Ken Kelley Chapter 34. Getting Started: Working With Secondary Data Amy M. Pienta, JoAnne McFarland O'Rourke, and Melissa M. Franks Chapter 35. How to Build Up Big Team Science: A Practical Guide for Large-Scale Collaborations Heidi A. Baumgartner, Nicolas Alessandroni, Krista Byers-Heinlein, Michael C. Frank, J. Kiley Hamlin, Melanie Soderstrom, Jan G. Voelkel, Robb Willer, Francis Yuen, and Nicholas A. Coles Part IX. Ethics and Scientific Integrity Guidelines and Codes Chapter 36. Ethical Principles of Psychologists and Code of Conduct American Psychological Association Chapter 37. Research Ethics: How to Treat People Who Participate in Research Ezekiel Emanuel, Emily Abdoler, and Leanne Stunkel Professional Responsibilities for the Conduct of Research Chapter 38. International Recommendations to Guide Multiple Facets of the Research and Publication Process Alan E. Kazdin Chapter 39. False-Positive Psychology: Undisclosed Flexibility in Data Collection and Analysis Allows Presenting Anything as Significant Joseph P. Simmons, Leif D. Nelson, and Uri Simonsohn Chapter 40. Best Practices for Allocating Appropriate Credit and Responsibility to Authors of Multi-Authored Articles Lucas D. Eggert Part X. Open Science, Replication, and Research Practices Open Science Chapter 41. A Manifesto for Reproducible Science Marcus R. Munafo, Brian A. Nosek, Dorothy V. M. Bishop, Katherine S. Button, Christopher D. Chambers, Nathalie Percie du Sert, Uri Simonsohn, Eric-Jan Wagenmakers, Jennifer J. Ware, and John P. A. Ioannidis Chapter 42. Replicate Others as You Would Like to Be Replicated Yourself Nicole Janz and Jeremy Freese Practices to Improve Research Chapter 43. A Template for Preregistration of Quantitative Research in Psychology: Report of the Joint Psychological Societies Preregistration Task Force Michael Bosnjak, Christian J. Fiebach, David Mellor, Stefanie Mueller, Daryl B. O'Connor, Frederick L. Oswald, and Rosemarie I. Sokol Chapter 44. Responsible Practices for Data Sharing George Alter and Richard Gonzalez Part XI. Publication and Communication of Research Reporting Standards: What to Cover and Include in an Article Chapter 45. Journal Article Reporting Standards for Quantitative Research in Psychology: The APA Publications and Communications Board Task Force Report Mark Appelbaum, Harris Cooper, Rex B. Kline, Evan Mayo-Wilson, Arthur M. Nezu, and Stephen M. Rao Communicating Research Findings Chapter 46. Publication and Communication of Research Findings Alan E. Kazdin Part XII. Perspectives on Methodology Chapter 47. Methodology: Perspectives and General Lessons to Guide Research Alan E. Kazdin Index About the Editor
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