This is an abundantly illustrated resource for diagnosis of bone and soft tissue lesions-a particular challenge due to their rarity and complexity. In addition to carefully selected histologic photographs, this unique atlas enhances standard visual information with illustrations of imaging findings, cytology, and molecular and cytogenetic information. This vivid pictorial survey is arranged in a pattern-oriented approach based on the actual working method used in daily practice. The authors are expert educators in surgical and cytopathology and experienced diagnosticians in the complexities of soft tissue and bone pathology. This richly illustrated and concise reference will be a practical and indispensible tool for general pathologists and pathologists in training, who are required to diagnose bone and soft tissue pathologies. It is also an excellent resource for physicians seeking a quick survey of sarcoma. Key Features:* Offers a practical, pattern-oriented diagnostic approach that mirrors the working method used in daily practice* Augments histologic photographs with illustrations of imaging findings, cytology, and molecular and cytogenetic information* Authored by recognized expert diagnosticians and teachers in the field
* Preface* Acknowledgments* PART I: OVERVIEW*1. Introduction*2. Principles of Diagnosis*2.1 Specimen Type and Procurement*2.2 Ancillary Testing*2.3 Tumor Grading and Staging*3. Clinical and Radiographic Features*3.1 Clinical Information*3.2 Imaging of Soft Tissue and Bone Tumors Jamie T. Caracciolo* PART II: TUMORS OF SOFT TISSUE*4. Tumors With Adipose Differentiation*4.1 Lipoma With Variants*4.2 Spindle Cell/Pleomorphic Lipoma*4.3 Hibernoma*4.4 Lipoblastoma*4.5 Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma*4.6 Dedifferentiated Liposarcoma*5. Tumors With Myxoid Stroma*5.1 Ganglion Cyst*5.2 Myxoma*5.3 Aggressive Angiomyxoma*5.4 Myxoid Liposarcoma*5.5 Extraskeletal Myxoid Chondrosarcoma*5.6 Myxofibrosarcoma (High Grade) *6. Benign and Low-Grade Spindle Cell Tumors*6.1 Fibromas*6.2 Elastofibroma*6.3 Fibromatosis*6.4 Neurofibroma*6.5 Schwannoma*6.6 Perineurioma*6.7 Nodular Fasciitis*6.8 Additional Variants of Fasciitis*6.9 Angiomyofibroblastoma*6.10 Cellular Angiofibroma*6.11 Myofibroblastoma*6.12 Gastrointestinal Stromal Tumor*6.13 Leiomyoma*6.14 Myofibroma and Myofibromatosis*6.15 Solitary Fibrous Tumor*6.16 Low-Grade Fibromyxoid Sarcoma*7. Intermediate- to High-Grade Spindle Cell Tumors*7.1 Leiomyosarcoma*7.2 Dermatofibrosarcoma Protuberans*7.3 Infantile Fibrosarcoma*7.4 Adult Fibrosarcoma*7.5 Malignant Peripheral Nerve Sheath Tumor*7.6 Spindle Cell/Sclerosing Rhabdomyosarcoma*7.7 Synovial Sarcoma*8. Epithelioid Soft Tissue Tumors*8.1 Rhabdomyoma*8.2 Granular Cell Tumor*8.3 Glomus Tumor*8.4 Neoplasms With Perivascular Epithelioid Cell Differentiation (PEComa) *8.5 Myoepithelial Tumors of Soft Tissue*8.6 Clear Cell Sarcoma*8.7 Epithelioid Sarcoma*8.8 Alveolar Soft Part Sarcoma*9. Small Round Blue Cell Tumors*9.1 Embryonal Rhabdomyosarcoma*9.2 Alveolar Rhabdomyosarcoma*9.3 Desmoplastic Small Round Cell Tumor*9.4 Extrarenal Rhabdoid Tumor*9.5 Melanotic Neuroectodermal Tumor of Infancy*10. Giant Cell-Rich Tumors*10.1 Plexiform Fibrohistiocytic Tumor*10.2 Tenosynovial Giant Cell Tumors*10.3 Giant Cell Tumor of Soft Tissue*11. Soft Tissue Tumors With Inflammation*11.1 Angiomatoid Fibrous Histiocytoma*11.2 Myxoinflammatory Fibroblastic Sarcoma*11.3 Inflammatory Myofibroblastic Tumor*11.4 IgG4-Related Diseases*12. Vascular Tumors*12.1 Hemangiomas*12.2 Hemangioendothelioma*12.3 Kaposi Sarcoma*12.4 Angiosarcoma*13. Pleomorphic Soft Tissue Tumors*13.1 Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts*13.2 Pleomorphic Liposarcoma*13.3 Pleomorphic Myogenic Sarcomas (Rhabdomyosarcoma and Leiomyosarcoma) *13.4 Intimal Sarcoma*13.5 Undifferentiated/Pleomorphic Sarcoma*14. Soft Tissue Tumors With Osseous or Cartilaginous Matrix*14.1 Myositis Ossificans*14.2 Phosphaturic Mesenchymal Tumor*14.3 Tumoral Calcinosis*14.4 Synovial Chondromatosis*14.5 Ossifying Fibromyxoid Tumor of Soft Parts*14.6 Extraskeletal Osteosarcoma and Chondrosarcoma* PART III. TUMORS OF BONE*15. Osseous Lesions*15.1 Osteoma*15.2 Osteoid Osteoma*15.3 Osteoblastoma*15.4 Osteosarcoma*15.5 Major Histologic Variants of Osteosarcoma*15.6 Parosteal Osteosarcoma*15.7 Periosteal Osteosarcoma*16. Cartilaginous Lesions*16.1 Enchondroma*16.2 Osteochondroma and Bizarre Parosteal Osteochondromatous Proliferation (Nora's Lesion) *16.3 Chondroblastoma*16.4 Chondromyxoid Fibroma*16.5 Chordoma*16.6 Chondrosarcoma*16.7 Clear Cell Chondrosarcoma*17. Giant Cell-Rich Lesions*17.1 Langerhans Cell Histiocytosis (Eosinophilic Granuloma) *17.2 Giant Cell Lesion of Small Bones (Giant Cell Reparative Granuloma) *17.3 Giant Cell Tumor of Bone*18. Spindle Cell Tumors*18.1 Fibrous Dysplasia*18.2 Nonossifying Fibroma*18.3 Osteofibrous Dysplasia*18.4 Adamantinoma*18.5 Desmoplastic Fibroma of Bone*18.6 Undifferentiated High-Grade Sarcoma of Bone*19. Small Round Blue Cell Tumors*19.1 Ewing Sarcoma and Primitive Neuroectodermal Tumor*19.2 Lymphoma of Bone*19.3 Plasmacytoma*19.4 Mesenchymal Chondrosarcoma*20. Cystic Lesions*20.1 Aneurysmal Bone Cyst*20.2 Simple Bone Cyst* Selected Readings* Index
