This glycobiology book is truly unique. Produced to commemorate the 80th birthday of Nathan Sharon, Glycobiology is an essential reference tool for anyone working in the field. Most research review volumes are narrowly focused. This book is different. It is a state-of-the-art fully comprehensive review volume covering a deliberately wide spectrum of work in this important field. With 28 chapters, covering over 350 pages, this title describes the latest research findings - from chemistry to biology and from pure science to industrial and medical applications. The book is written by world-class researchers and brings the reader fully up-to-date with the latest advances and forward thinking. All the major areas of glycobiology are covered including the synthesis of carbohydrates and glycoconjugates, their structural and functional analysis, carbohydrate binding proteins, carbohydrate modifying enzymes, and the applications of glycobiology research in medicine and industry. All active researchers in the glycosciences will value access to this important research compendium whether it be in the local library or in the lab.
SECTION 1. Introduction 1. Half a century at the carbohydrate-protein interface Clare Sansom, Birkbeck College 2. Glycobiology - discovery, diagnostics and drugs Raymond Dwek et al., University of Oxford SECTION 2. Synthesis of Carbohydrate and Glycoconjugates 3. Sugar-lectin interactions: glycotargeting with synthetic glycoconjugates Michel Monsigny et al., CNRS Orleans 4. Recent developments in the synthesis and application of sialylmimetics Hansjoerg Streicher and Heike Busse, University of Sussex SECTION 3. Analysis and Structure 5. Structure and function of the chondroitin/dermatan sulfates Robert Lauder, Lancaster University 6. Revealing the hidden dimensions of glycosaminoglycans in solution and protein complexes with saccharide libraries, FTIR, and SRCD David Fernig et al., University of Liverpool 7. Structural determination of N-linked glycans by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry David Harvey, University of Oxford 8. Integrated approach to glycan structure-function relationships Ram Sasisekharan, MIT SECTION 4. Cell Biology of Carbohydrates and Glycoproteins 9. Some observations on the biology of cell surface heparan sulfate proteoglycans John Gallagher, Christie Hospital Manchester 10. Galectins: effective modulators of cytoskeletal organization and cellular growth - focus on galectin-8 as a model system Yehiel Zick, Weizmann Institute of Science 11. Intracellular lectin involvement in glycoprotein maturation and quality control in the secretory pathway Gerardo Lederkremer, Tel Aviv University SECTION 5. Carbohydrate-Binding Proteins 12. The diversity of sialic acids and their interplay with lectins Roland Schauer, Biochemisches Institut Kiel 13. Structure and carbohydrate specificity of -prism I fold lectins M. Vijayan, V. Surolia and K. Sekar, Indian Institute of Science 14. Protein-glycan interactions in immunoregulation: galectins as tuners of the inflammatory response Gabriel Rabinovich, University of Buenos Aires 15. Recognition of bacterial glycoepitopes by pulmonary C-type lectins as an arm of lung innate immunity Itzhak Ofek, Tel Aviv University 16. Selectin and integrin recognition of ligands under shear flow: affinity and beyond Ronen Alon, Weizmann Institute of Science SECTION 6. Carbohydrate-Modifying Enzymes 17. Complex carbohydrate-modifying enzymes Spencer Williams, University of Melbourne 18. Glycosyltransferases specific for the synthesis of mucin-type O-glycans Inka Brockhausen, Queen's University, Ontario 19. Glycosylation in development Pamela Stanley, Albert Einstein College of Medicine, New York SECTION 7. Glycobiology and Medicine 20. Glycobiology of mucins in the human gastrointestinal tract Anthony Corfield, Mucin Research Group, University of Bristol 21. Mucosal glycoconjugates in inflammatory bowel disease and colon cancer Jon Rhodes, University of Liverpool 22. Selectin-mediated metastasis of tumor cells: Alteration of carbohydrate-mediated cell-cell interactions in cancers induced by epigenetic silencing of glycogenes Reiji Kannagi, Nagoya City University 23. Glycosphingolipids in health and disease Tony Futerman, Weizmann Institute of Science 24. Pathogen-host interactions in Entamoeba histolytica David Mirelman, Weizmann Institute of Science SECTION 8. Industrial Glycobiology 25. The development of iminosugars as drugs Bryan Winchester, Institute of Child Health 26. Carbohydrate biosensors Raz Jelinek, Ben Gurion University 27. Glycoanalysis on a lectin array: application to the development of biopharmaceuticals and life science research Rakefet Rosenfeld, Procognia 28. Lectin chips and CarboDeep (TM): a rapid carbohydrate fingerprinting technology and its application for the food scientists Ofer Markman, Nutricognia Afterword Nathan Sharon
